Voici les publications académiques avant 2006

Core in-vivo toxicokinetics / disposition

• 1991 — PFOA tissue distribution + elimination (sex differences) in rats
  Vanden Heuvel JP, et al. J Biochem Toxicol (1991).
  DOI: 10.1002/jbt.2570060202 PubMed
  Why it matters: Classic radiolabeled study quantifying tissue distribution (notably liver/plasma) and marked sex differences in elimination.
• 1992 — PFOA persistence and time course of hepatic response in mice
  Sohlenius AK, et al. J Biochem Toxicol (1992).
  DOI: 10.1002/jbt.2570070403 PubMed
  Why it matters: Demonstrates persistence over time (biological effect readouts) consistent with slow clearance/retention dynamics.
• 2001 — PFCA chain length vs elimination (urine/feces; sex/hormone effects) in rats
  Kudo N, et al. Chem Biol Interact (2001).
  DOI: 10.1016/S0009-2797(01)00155-7 PubMed
  Why it matters: Establishes how carbon chain length and sex shift elimination kinetics—foundational for understanding why long-chain PFAS persist.
• 2002 — Mechanistic renal transport control of PFOA by sex hormones (rats)
  Kudo N, et al. Chem Biol Interact (2002).
  DOI: 10.1016/S0009-2797(02)00006-6 PubMed
  Why it matters: Directly links renal clearance to organic anion transporter biology and hormonal regulation, explaining large male/female TK differences in rodents.
• 2003 — PFOS sub-chronic rat study with serum/liver concentration context
  Seacat AM, et al. Toxicology (2003).
  DOI: 10.1016/S0300-483X(02)00511-5 ScienceDirect
  Why it matters: While framed as toxicity, it reports dose–concentration relationships (serum/liver) and supports accumulation/steady-state concepts for PFOS.
• 2002 — PFOS primate study with recovery phase (serum/liver decline post-dosing)
  Seacat AM, et al. Toxicol Sci (2002).
  DOI: 10.1093/toxsci/68.1.249 PubMed
  Why it matters: Key early dataset on PFOS in primates, including post-exposure decline (important for human-relevant TK inference).
• 2003 — Review-style synthesis of PFOA TK mechanisms (distribution, renal/fecal excretion, enterohepatic hints)
  Kudo N, Kawashima Y. J Toxicol Sci (2003).
  DOI: 10.2131/jts.28.49 PubMed
  Why it matters: Consolidates then-known mechanisms: liver/plasma distribution, urine + feces excretion, renal transport emphasis, and discussion of enterohepatic circulation concepts. PubMed

Protein binding / distribution drivers

• 2004 — PFOA binding to rat and human plasma proteins (distribution determinant)
  Chem Res Toxicol (2004).
  DOI: 10.1021/tx034005w American Chemical Society Publications
  Why it matters: Protein binding is a major determinant of volume of distribution, filtration, and persistence—this is one of the canonical binding papers.
• 2002 — Fluorochemical interactions with rat liver fatty acid–binding protein (L-FABP)
  Luebker DJ, et al. Toxicology (2002).
  DOI: 10.1016/S0300-483X(02)00081-1 PubMed
  Why it matters: Supports mechanistic hypotheses for hepatic retention/interaction (relevant to distribution and potential reabsorption pathways).

Primate pharmacokinetics

• 2004 — PFOA pharmacokinetics in cynomolgus monkeys (oral + IV; serum half-life; urinary route)
  Butenhoff JL, et al. Toxicol Sci (2004).
  DOI: 10.1093/toxsci/kfh302 PubMed
  Why it matters: One of the most cited non-rodent TK datasets for PFOA, critical for cross-species scaling before modern PBPK models.

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Comme on peut le voir, je n’ai demandé QUE les publications avec un DOI = dans le registre des publications académiques.